The Science

Our understanding of chromatin structure and function has allowed us to mine the genome for gene regulatory elements that can be used in synthetic promoter design.

The Blueprint for life


The genome is the blueprint for life, comprising all the genes that encode living organisms and many sequences of unknown function


  • Genes correspond to only 1% of the complete sequence of the genome, the rest is referred to as genome dark matter.
  • The emergence of functional genomics has resulted in the generation of many large datasets that can be mined and used to decode genomic dark matter.

What Chromatin Reveals


The genome is painted with a vast array of protein and chemical epigenetic signals to form a structure called chromatin


  • Epigenetic signals control how the genome is structured and also how it regulates itself in different cell types.
  • Functional genomics data allows us to look at epigenetic signals and determine which genome sequences control gene expression in specific conditions.

Leveraging Gene Regulation


By studying functional genomics datasets, we can uncover gene regulatory elements active in response to a specific cell type, time/stage or stimulus


  • Genomic elements can be isolated and re-purposed to create novel gene expression vectors active at pre-defined levels, selective in certain cell types, controlled in a temporal manner, or responsive to specific stimuli.
  • Such vectors have broad application across the biotech industry.
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